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No increased risk has been shown for adults over age 24, and risk decreased for those over age 65. Other studies in mice reported in the literature using higher doses to 15 mg kg day have described maternal toxicity and death, increased fetal resorptions, and fetal malformations. Maximum daily dosage should not exceed mg kg day or 150-200 mg day, whichever is less. As advancing years appear to increase the possibility of adverse reactions, Indocin should be used with greater care in the elderly see PRECAUTIONS, Geriatric Use. 177 230 231 Also, studies with 600 mg of etodolac per day 265 have not shown differences in the side effects profile of etodolac in geriatric patients compared with younger kober billige indomethacin med visum guld adults. Patients on long-term treatment with NSAIDs, including INDOCIN, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia.